The most common ailment affecting the oral cavity is infectious stomatitis, which is caused by factors including inadequate oral hygiene, long-term use of antibiotics, smoking, presence of dental prostheses, and immunodeficiency or systemic disease (e.g., HIV, diabetes mellitus, and oncological illnesses), which allow the overgrowth of microorganisms and subsequent outbreak of inflammation in the oral cavity. It consists of aerobic and anaerobic microorganisms whose representation depends on several factors (e.g., age, composition of food, medication, lesions in the oral cavity, systemic diseases, or infections). The oral microflora is a very specific component of the human organism. In addition to its promising physicomechanical, chemical, and mucoadhesive properties, the formulation inhibited the growth of Staphylococcus and Candida the effect was prolonged for tens of hours. Generally, the best results were obtained with sample containing 20 mg of chlorhexidine diacetate carried by vermiculite, with carmellose in the form of nonwoven textile in its structure. This evaluation was complemented by testing the antimicrobial and antimycotic activity of prepared films with the aim of finding the most suitable composition for clinical application. The multivariate data analysis was employed to evaluate the influence of the formulation and process variables on the properties of the medical preparation. This study describes the unique approach of preparing mucoadhesive oral films from carmellose with incorporating a nanotechnologically modified clay mineral intercalated with chlorhexidine. This formulation consists of a mucoadhesive oral film with incorporated nanocomposite biomaterial that is able to release the drug directly at the target area. An innovative application form based on bioadhesive polymers featuring prolonged residence time on the oral mucosa may be a solution to this challenge.
Current therapy is insufficiently effective because of the short residence time of topical liquid or semisolid medical formulations. #GalleryĪgartala : A farmer working on vegetable farm.Infectious stomatitis represents the most common oral cavity ailments. Mumbai:India’s captain Virat Kohli, right, along with Shubman Gill take run during the day three of their second test cricket match with New Zealand. Mumbai:New Zealand’s Rachin Ravindra, left, celebrates the dismissal of India’s Virat Kohli with his team players during the day three of their second test cricket match with India. Mumbai:India’s captain Virat Kohli is bowled during the day three of their second test cricket match with New Zealand. Guwahati: Angry villagers torch vehicles of security personnel after 13 civilians were killed by security forces in Nagaland’s Mon district #Gallery New Delhi:Punjab Congress president Navjot Singh Sidhu join guest teacher protest near Delhi CM Arvind Kejriwal residence. New Delhi:Punjab Congress president Navjot Singh Sidhu talk to media as he join guest teacher protest near Delhi CM Arvind Kejriwal residence. Mumbai:India’s Shubman Gill plays shot during the day three of their second test cricket match with New Zealand. Mumbai:India’s Shreyas Iyer plays shot during the day three of their second test cricket match with New Zealand. Mumbai:India’s captain Virat Kohli – reacts during the day three of their second test cricket match with New Zealand.
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